Also known as: TPO; Thyroid Peroxidase
Autoantibodies directed against thyroid peroxidase (TPO) in thyroid microsomes are the most important autoantibodies detected in the serum of patients with autoimmune thyroiditis. The presence of thyroid antibodies correlates very closely with lymphocyte infiltration in the thyroid gland characteristic of autoimmune thyroiditis. These antibodies are present in:
- 60% of cases of Graves' disease
- 90% of cases of Hasimoto's thyroiditis (high titre)
- 80% of cases of primary myxoedema
Low titre anti-TPO antibodies maybe found in thyroid carcinoma, transiently in post-viral thyroiditis and rarely in colloid goitre. Persistently high thyroid antibodies predict the onset of hypothyroidism.
Specimen requirements
Serum 1ml
Cost
Price on application
Laboratory turnaround time
3 days
Laboratory method
Immunocap automated Enzyme Immunoassay
Reference range/units
>100 IU/ml = Positive
60-100 IU/ml = Equivocal
60IU/ml = Negative
Associated tests
Thyroid Stimulatory Receptor Antibodies
Sample stability
2 months at 2-8ºC
Shipping and storage
UK and Ireland
Ambient temperature and first class post. Hays DX users please enquire via email below.
International
Ambient temperature if courier will deliver within 72 hours otherwise consider refrigerated transport. Freezing is not a requirement.
Ensure delivery Monday to Friday 09:00 - 17:30.
Further information and contact details
For further information, email immunologylab.enquiries@ouh.nhs.uk
